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Article

MicroRNA-1 targets Slug and endows lung cancer A549 cells with epithelial and anti-tumorigenic properties

7 Nov 2012

Abstract excerpt

MicroRNA-1 (miR-1) has recently been suggested to function as a tumor suppressor. Its functional relevance was assessed by exploring structural and tumorigenic properties of lung cancer A549 cells stably transduced with retrovirus containing pre-miR-1. A549 cells overexpressing miR-1 exhibited a significant morphological change from a mesenchymal to an epithelial phenotype characterized by cell polarization and...

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PMID: 23142026
DOI: 10.1016/j.yexcr.2012.10.015

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