Article
RNAi-mediated silencing of VEGF-C inhibits non-small cell lung cancer progression by simultaneously down-regulating the CXCR4, CCR7, VEGFR-2 and VEGFR-3-dependent axes-induced ERK, p38 and AKT signalling pathways.
European journal of cancer (Oxford, England : 1990) - 1 Oct 2011
Feng Yukuan, Hu Jing, Ma Jing, Feng Kejian, Zhang Xiaoli, Yang Shucai, Wang Wei, Zhang Jianguo, Zhang Yafang
Abstract excerpt
Vascular endothelial growth factor C (VEGF-C) expression is associated with the malignant tumour phenotype making it an attractive therapeutic target. We investigated the biological roles of VEGF-C in tumour growth, migration, invasion and explored the possibility of VEGF-C as a potential therape...
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