Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

E7080 suppresses hematogenous multiple organ metastases of lung cancer cells with nonmutated epidermal growth factor receptor.

Molecular cancer therapeutics - 1 Jul 2011

Ogino Hirokazu, Hanibuchi Masaki, Kakiuchi Soji, Trung Van The, Goto Hisatsugu, Ikuta Kenji, Yamada Tadaaki, Uehara Hisanori, Tsuruoka Akihiko, Uenaka Toshimitsu, Wang Wei, Li Qi, Takeuchi Shinji, Yano Seiji, Nishioka Yasuhiko, Sone Saburo

Abstract excerpt

While epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors improve the prognosis of patients with EGFR mutant lung cancer, the prognosis of patients with nonmutant EGFR lung cancer, especially those with metastases, is still extremely poor. We have assessed the therapeutic efficacy...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endothelial Cells
Share to Mice, Nude

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, SCID

Share to Phenylurea Compounds

Share to Quinolines

Share to Receptors, Vascular Endothelial Growth Factor

Share to Tumor Burden

Share to Vascular Endothelial Growth Factors

Source

Identifiers

PMID: 21551260
DOI: 10.1158/1535-7163.MCT-10-0707

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21551260-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

E7080 suppresses hematogenous multiple organ metastases of lung cancer cells with nonmutated epidermal growth factor receptor.PMID 21551260Read ↗

RNAi-mediated silencing of VEGF-C inhibits non-small cell lung cancer progression by simultaneously down-regulating the CXCR4, CCR7, VEGFR-2 and VEGFR-3-dependent axes-induced ERK, p38 and AKT signalling pathways.Semantic proximity Read ↗

Lung Endothelial MicroRNA-1 Regulates Tumor Growth and AngiogenesisSemantic proximity Read ↗

VEGF neutralizing aerosol therapy in primary pulmonary adenocarcinoma with K-ras activating-mutations.Semantic proximity Read ↗

CM082, a novel angiogenesis inhibitor, enhances the antitumor activity of gefitinib on epidermal growth factor receptor mutant non-small cell lung cancer in vitro and in vivo.Semantic proximity Read ↗

Sunitinib prolongs survival in genetically engineered mouse models of multistep lung carcinogenesis.Semantic proximity Read ↗

Orthotopic model of lung cancer: isolation of bone micro-metastases after tumor escape from Osimertinib treatment.Semantic proximity Read ↗

Bevacizumab counteracts VEGF-dependent resistance to erlotinib in an EGFR-mutated NSCLC xenograft model.Semantic proximity Read ↗

Role of C-X-C chemokines as regulators of angiogenesis in lung cancerSemantic proximity Read ↗

[Effect of EGFR-TKI on lymphangiogenesis of lung cancer with EGFR mutation].Semantic proximity Read ↗

Correlation between plasma DNA and tumor status in an animal model.Semantic proximity Read ↗

Inhibition of Tumor Metastasis by a Growth Factor Receptor Bound Protein 2 Src Homology 2 Domain–Binding AntagonistSemantic proximity Read ↗

Immunohistopathological characterizatin of spontaneous metastases in a human lung mucoepidermoid adenocarcinoma (HLMC) xenograft.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.