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Article

Skeletal Site-specific Changes in Bone Mass in a Genetic Mouse Model for Human 15q11-13 Duplication Seen in Autism.

Scientific reports - 29 Aug 2017

Lewis Kirsty E, Sharan Kunal, Takumi Toru, Yadav Vijay K

Abstract excerpt

Children suffering from autism have been reported to have low bone mineral density and increased risk for fracture, yet the cellular origin of the bone phenotype remains unknown. Here we have utilized a mouse model of autism that duplicates 6.3 Mb region of chromosome 7 (Dp/+) corresponding to a region of chromosome 15q11-13, duplication of which is recurrent in humans to characterize the bone phenotype....

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Identifiers

PMID: 28851986
DOI: 10.1038/s41598-017-09921-8
PMCID: PMC5575059

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