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Article

Postnatal brain and skull growth in an Apert syndrome mouse model.

American journal of medical genetics. Part A - 1 Apr 2013

Hill Cheryl A, Martínez-Abadías Neus, Motch Susan M, Austin Jordan R, Wang Yingli, Jabs Ethylin Wang, Richtsmeier Joan T, Aldridge Kristina

Abstract excerpt

Craniofacial and neural tissues develop in concert throughout prenatal and postnatal growth. FGFR-related craniosynostosis syndromes, such as Apert syndrome (AS), are associated with specific phenotypes involving both the skull and the brain. We analyzed the effects of the FGFR P253R mutation for AS using the Fgfr2(+/P253R) Apert syndrome mouse to evaluate the effects of this mutation on these two tissues over...

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Identifiers

PMID: 23495236
DOI: 10.1002/ajmg.a.35805
PMCID: PMC3606655

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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