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Article

Identification of novel genetic loci for bone size and mechanosensitivity in an ENU mutant exhibiting decreased bone size.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jun 2005

Srivastava Apurva K, Kapur Sanjay, Mohan Suburaman, Yu Hongrun, Kapur Sonia, Wergedal Jon, Baylink David J

Abstract excerpt

UNLABELLED: Using a dominant ENU mutagenesis screen in C57BL/6J (B6) mice to reveal gene function, we identified a mutant, 917M, with a reduced bone size phenotype, which is expressed only in males. We show that mutation results in osteoblasts with reduced proliferation, increased apoptosis, and an impaired response to in vitro mechanical load. The mutation is mapped to a novel locus (LOD score of 7.9 at 10.5 cM)...

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Identifiers

PMID: 15883645
DOI: 10.1359/JBMR.041239

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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