Article

Regulatory network topology and the genetic architecture of gene expression

2025-08-13

Abstract excerpt

In human populations, most of the genetic variance in gene expression can be attributed to trans -acting expression quantitative trait loci (eQTLs) spread across the genome. However, in practice it is difficult to discover these eQTLs, and their cumulative effects on gene expression and complex traits are yet to be fully understood. Here, we assess how properties of the genetic architecture of gene expression con...

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Literature Corpus work: f0389bfb-5a55-555d-82a3-720d66cca331
DOI: 10.1101/2025.08.12.669924

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