Article

Expression of ALS-PFN1 impairs vesicular degradation in iPSC-derived microglia

2023-06-01

Abstract excerpt

<h4>ABSTRACT</h4> Microglia play a pivotal role in neurodegenerative disease pathogenesis, but the mechanisms underlying microglia dysfunction and toxicity remain to be fully elucidated. To investigate the effect of neurodegenerative disease-linked genes on the intrinsic properties of microglia, we studied microglia-like cells derived from human induced pluripotent stem cells (iPSCs), termed iMGs, harboring mutat...

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Literature Corpus work: 44989553-a686-5a7b-bc94-33e905d37b6f
DOI: 10.1101/2023.06.01.541136

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