Article
Neutral tumor evolution in myeloma is associated with poor prognosis.
Blood - 5 Oct 2017
Johnson David C, Lenive Oleg, Mitchell Jonathan, Jackson Graham, Owen Roger, Drayson Mark, Cook Gordon, Jones John R, Pawlyn Charlotte, Davies Faith E, Walker Brian A, Wardell Christopher, Gregory Walter M, Cairns David, Morgan Gareth J, Houlston Richard S, Kaiser Martin F
Abstract excerpt
Recent studies suggest that the evolutionary history of a cancer is important in forecasting clinical outlook. To gain insight into the clonal dynamics of multiple myeloma (MM) and its possible influence on patient outcomes, we analyzed whole exome sequencing tumor data for 333 patients from Myeloma XI, a UK phase 3 trial and 434 patients from the CoMMpass study, all of which had received immunomodulatory drug...
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