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Article

Mutational processes contributing to the development of multiple myeloma

6 Aug 2019

Abstract excerpt

To gain insight into multiple myeloma (MM) tumorigenesis, we analyzed the mutational signatures in 874 whole-exome and 850 whole-genome data from the CoMMpass Study. We identified that coding and non-coding regions are differentially dominated by distinct single-nucleotide variant (SNV) mutational signatures, as well as five de novo structural rearrangement signatures. Mutational signatures reflective of...

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PMID: 31387987
DOI: 10.1038/s41408-019-0221-9

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