Article
The molecular make up of smoldering myeloma highlights the evolutionary pathways leading to multiple myeloma.
Nature communications - 12 Jan 2021
Boyle Eileen M, Deshpande Shayu, Tytarenko Ruslana, Ashby Cody, Wang Yan, Bauer Michael A, Johnson Sarah K, Wardell Christopher P, Thanendrarajan Sharmilan, Zangari Maurizio, Facon Thierry, Dumontet Charles, Barlogie Bart, Arbini Arnaldo, Rustad Even H, Maura Francesco, Landgren Ola, Zhan Fenghuang, van Rhee Frits, Schinke Carolina, Davies Faith E, Morgan Gareth J, Walker Brian A
Abstract excerpt
Smoldering myeloma (SMM) is associated with a high-risk of progression to myeloma (MM). We report the results of a study of 82 patients with both targeted sequencing that included a capture of the immunoglobulin and MYC regions. By comparing these results to newly diagnosed myeloma (MM) we show fewer NRAS and FAM46C mutations together with fewer adverse translocations, del(1p), del(14q), del(16q), and del(17p) in...
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