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Article

Whole-genome analysis identifies novel drivers and high-risk double-hit events in relapsed/refractory myeloma

12 Oct 2022

Abstract excerpt

Large-scale analyses of genomic data from patients with newly diagnosed multiple myeloma (ndMM) have been undertaken, however, large-scale analysis of relapsed/refractory MM (rrMM) has not been performed. We hypothesize that somatic variants chronicle the therapeutic exposures and clonal structure of myeloma from ndMM to rrMM stages. We generated whole-genome sequencing (WGS) data from 418 tumors (386 patients)...

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PMID: 36223594
DOI: 10.1182/blood.2022017010

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