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Article

Subtyping of Type 1 Diabetes as Classified by Anti-GAD Antibody, IgE Levels, and Tyrosine kinase 2 (TYK2) Promoter Variant in the Japanese.

EBioMedicine - 1 Sept 2017

Mine Keiichiro, Hirakawa Kanako, Kondo Shiori, Minami Masae, Okada Akira, Tsutsu Nobutaka, Yokogawa Yasushi, Hibio Yumi, Kojima Fumiko, Fujimoto Shuji, Kurisaki Hironori, Anzai Keizo, Yoshikai Yasunobu, Nagafuchi Seiho

Abstract excerpt

OBJECTIVE: Type 1 diabetes (T1D) is known to be caused by Th1 cell-dependent autoimmunity. Recently, we reported that TYK2 promoter variant serves as a putative virus-induced diabetes susceptibility gene associated with deteriorated interferon-dependent antiviral response. TYK2 is also related to HIES, that is, Th2 cell-dependent. Therefore, TYK2 promoter variant may be also associated with the pathogenesis of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28826655
DOI: 10.1016/j.ebiom.2017.08.012
PMCID: PMC5605380

Genes

TYK2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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