TYK2 Promoter Variant and Diabetes Mellitus in the Japanese.

doi:10.1016/j.ebiom.2015.05.004

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TYK2 Promoter Variant and Diabetes Mellitus in the Japanese.

EBioMedicine - 1 Jul 2015

Nagafuchi Seiho, Kamada-Hibio Yumi, Hirakawa Kanako, Tsutsu Nobutaka, Minami Masae, Okada Akira, Kai Katsuya, Teshima Miho, Moroishi Arisa, Murakami Yoshikazu, Umeno Yoshikazu, Yokogawa Yasushi, Kogawa Kazuhiko, Izumi Kenichi, Anzai Keizo, Iwakiri Ryuichi, Hamaguchi Kazuyuki, Sasaki Nobuhiro, Nohara Sakae, Yoshida Eiko, Harada Mine, Akashi Koichi, Yanase Toshihiko, Ono Junko, Okeda Toshimitsu, Fujimoto Ryoji, Ihara Kenji, Hara Toshiro, Kikuchi Yohei, Iwase Masanori, Kitazono Takanari, Kojima Fumiko, Kono Suminori, Kurisaki Hironori, Kondo Shiori, Katsuta Hitoshi

Abstract excerpt

BACKGROUND: Recently, natural mutation of Tyrosine kinase 2 (Tyk2) gene has been shown to determine susceptibility to murine virus-induced diabetes. In addition, a previous human genome-wide study suggested the type 1 diabetes (T1D) susceptibility region to be 19p13, where the human TYK2 gene is located (19p13.2). METHODS: Polymorphisms of TYK2 gene at the promoter region and exons were studied among 331 healthy...

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Identifiers

PMID: 26288847
DOI: 10.1016/j.ebiom.2015.05.004
PMCID: PMC4534683

Genes

TYK2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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