Article

Looking Across Protein Domains to Identify Driver Mutations in Cancer

2025-08-13

Abstract excerpt

Cancer can develop through the accumulation of somatic mutations that drive uncontrolled cell proliferation. A central objective in cancer research is to identify mutations that provide a selective growth advantage to tumor cells, so called driver mutations. Many computational methods infer driver missense mutations in proteins by assessing their recurrence. However, such approach suffers from the limited capacity...

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Literature Corpus work: af97c291-a339-5e04-a998-b3a1e464cba9
DOI: 10.1101/2025.08.11.669561

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