Article
Evaluating the maintenance of disease-associated variation at the blood group-related gene B4galnt2 in house mice.
BMC evolutionary biology - 14 Aug 2017
Vallier Marie, Abou Chakra Maria, Hindersin Laura, Linnenbrink Miriam, Traulsen Arne, Baines John F
Abstract excerpt
BACKGROUND: B4galnt2 is a blood group-related glycosyltransferase that displays cis-regulatory variation for its tissue-specific expression patterns in house mice. The wild type allele, found e.g. in the C57BL/6 J strain, directs intestinal expression of B4galnt2, which is the pattern observed among vertebrates, including humans. An alternative allele class found in the RIIIS/J strain and other mice instead...
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