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Article

Pathometagenomics reveals susceptibility to intestinal infection by Morganella to be mediated by the blood group-related B4galnt2 gene in wild mice.

Gut microbes - 1 Jan 2000

Vallier Marie, Suwandi Abdulhadi, Ehrhardt Katrin, Belheouane Meriem, Berry David, Čepić Aleksa, Galeev Alibek, Johnsen Jill M, Grassl Guntram A, Baines John F

Abstract excerpt

Infectious disease is widely considered to be a major driver of evolution. A preponderance of signatures of balancing selection at blood group-related genes is thought to be driven by inherent trade-offs in susceptibility to disease. B4galnt2 is subject to long-term balancing selection in house mice, where two divergent allele classes direct alternative tissue-specific expression of a glycosyltransferase in the...

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Identifiers

PMID: 36683151
DOI: 10.1080/19490976.2022.2164448
PMCID: PMC9872957

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