Article

A trade-off between resistance to infection and reproduction in primate evolution

2020-07-12

Abstract excerpt

<h4>SUMMARY</h4> Most mammals express a functional GGTA1 gene encoding the N-acetyllactosaminide α-1,3-galactosyltransferase enzyme, which synthesizes Galα1-3Galβ1-4GlcNAc (αGal) and are thus tolerant to this self-expressed glycan epitope. Old World primates including humans, however, carry GGTA1 loss-of-function mutations and lack αGal. Presumably, fixation of such mutations was propelled by natural selection,...

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Literature Corpus work: fd684395-a6b5-56fe-8472-c24f3b03112b
DOI: 10.1101/2020.07.10.186742

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