Article
The endothelial-specific regulatory mutation, Mvwf1, is a common mouse founder allele.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Jan 2008
Johnsen Jill M, Levy Gallia G, Westrick Randal J, Tucker Priscilla K, Ginsburg David
Abstract excerpt
Mvwf1 is a cis-regulatory mutation previously identified in the RIIIS/J mouse strain that causes a unique tissue-specific switch in the expression of an N-acetylgalactosaminyltransferase, B4GALNT2, from intestinal epithelium to vascular endothelium. Vascular B4galnt2 expression results in aberrant glycosylation of von Willebrand Factor (VWF) and accelerated VWF clearance from plasma. We now report that 13 inbred...
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