Article
A novel modifier gene for plasma von Willebrand factor level maps to distal mouse chromosome 11.
Proceedings of the National Academy of Sciences of the United States of America - 24 Dec 1996
Mohlke K L, Nichols W C, Westrick R J, Novak E K, Cooney K A, Swank R T, Ginsburg D
Abstract excerpt
Type 1 von Willebrand disease (VWD), characterized by reduced levels of plasma von Willebrand factor (VWF), is the most common inherited bleeding disorder in humans. Penetrance of VWD is incomplete, and expression of the bleeding phenotype is highly variable. In addition, plasma VWF levels vary w...
Topics
- Animals
- Base Sequence
- Chromosome Mapping
- Crosses, Genetic
- DNA Primers
- Enzyme-Linked Immunosorbent Assay
- Genetic Carrier Screening
- Genotype
- Homozygote
- Humans
- Mice
- Mice, Inbred Strains
- Molecular Sequence Data
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length