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Article

Modifiers of von Willebrand factor identified by natural variation in inbred strains of mice.

Blood - 17 Dec 2009

Shavit Jordan A, Manichaikul Ani, Lemmerhirt Heidi L, Broman Karl W, Ginsburg David

Abstract excerpt

Type 1 von Willebrand disease (VWD) is the most common inherited human bleeding disorder. However, diagnosis is complicated by incomplete penetrance and variable expressivity, as well as wide variation in von Willebrand factor (VWF) levels among the normal population. Previous work has exploited the highly variable plasma VWF levels among inbred strains of mice to identify 2 major regulators, Mvwf1 and Mvwf2...

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Share to Enzyme-Linked Immunosorbent Assay
Share to Gene Expression Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred Strains

Share to Polymorphism, Restriction Fragment Length

Share to Quantitative Trait Loci

Share to Regulatory Elements, Transcriptional

Share to Reverse Transcriptase Polymerase Chain Reaction

Share to von Willebrand Factor

Source

Open in PubMed Open full text

Identifiers

PMID: 19789385
DOI: 10.1182/blood-2009-07-233213
PMCID: PMC2796139

Genes

VWF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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