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Article

Selection on cis-regulatory variation at B4galnt2 and its influence on von Willebrand factor in house mice.

Molecular biology and evolution - 1 Mar 2009

Johnsen Jill M, Teschke Meike, Pavlidis Pavlos, McGee Beth M, Tautz Diethard, Ginsburg David, Baines John F

Abstract excerpt

The RIIIS/J inbred mouse strain is a model for type 1 von Willebrand disease (VWD), a common human bleeding disorder. Low von Willebrand factor (VWF) levels in RIIIS/J are due to a regulatory mutation, Mvwf1, which directs a tissue-specific switch in expression of a glycosyltransferase, B4GALNT2,...

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Source

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Identifiers

PMID: 19088380
DOI: 10.1093/molbev/msn284
PMCID: PMC2727395

Genes

VWF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19088380-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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