Article
A role of stochastic phenotype switching in generating mosaic endothelial cell heterogeneity.
Nature communications - 8 Jan 2016
Yuan Lei, Chan Gary C, Beeler David, Janes Lauren, Spokes Katherine C, Dharaneeswaran Harita, Mojiri Anahita, Adams William J, Sciuto Tracey, Garcia-Cardeña Guillermo, Molema Grietje, Kang Peter M, Jahroudi Nadia, Marsden Philip A, Dvorak Ann, Regan Erzsébet Ravasz, Aird William C
Abstract excerpt
Previous studies have shown that biological noise may drive dynamic phenotypic mosaicism in isogenic unicellular organisms. However, there is no evidence for a similar mechanism operating in metazoans. Here we show that the endothelial-restricted gene, von Willebrand factor (VWF), is expressed in a mosaic pattern in the capillaries of many vascular beds and in the aorta. In capillaries, the mosaicism is...
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