Pleiotropic loss of activation pathways in a T-cell receptor alpha-chain deletion variant of a cytolytic T-cell clone.

doi:10.1038/325628a0

Back to search

Article

Pleiotropic loss of activation pathways in a T-cell receptor alpha-chain deletion variant of a cytolytic T-cell clone.

Nature - 1 Jan 2000

Schmitt-Verhulst A M, Guimezanes A, Boyer C, Poenie M, Tsien R, Buferne M, Hua C, Leserman L

Abstract excerpt

Untransformed T-cell clones maintained in culture are dependent on signals transmitted through their antigen receptors (Ti; alpha and beta chains associated with the CD3 molecules) for growth and effector function. For cytolytic T cells (CTL), Ti stimulation also activates the killing machinery a...

Topics

Antibodies, Monoclonal
Antibody Specificity
Antigens, Surface
Calcium
Genetic Variation
Lymphocyte Activation
Receptors, Antigen, T-Cell
T-Lymphocytes, Cytotoxic
Thy-1 Antigens

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.