Article
Morphological, genetic and functional variability of a T-cell hybridoma line.
Folia biologica - 1 Jan 2003
Dzhambazov B, Teneva I, Koleva L, Asparuhova D, Popov N
Abstract excerpt
The variability in the morphology, modal number of chromosomes, TCR expression and functional reactivity of a CII-specific T-cell hybridoma at continuous subcultivation have been investigated. As the number of passages increased, besides the oval semiadherent cells (normal phenotype), fibroblast-like cells (transformed phenotype) were also observed. The two cell subpopulations differed in their karyotype...
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