Article
Cellular and molecular characteristics of transformed T cells from an antigen-specific T-cell line.
Scandinavian journal of immunology - 1 May 1990
Wegener A M, Holm B, Geisler C, Rubin B
Abstract excerpt
An antigen-specific T-cell line which transforms into T-lymphoma cells in vitro but apparently not in vivo is described. Membrane markers, tumorigenicity and T-cell receptor (TcR) V alpha and V beta-gene usage of the in vitro transformed T-cell line were analysed to investigate whether the transf...
Topics
- Animals
- Antibodies, Monoclonal
- Antigens, Neoplasm
- Blotting, Northern
- Blotting, Southern
- Cell Line, Transformed
- Cell Transformation, Neoplastic
- DNA Probes
- DNA, Neoplasm
- Epitopes
- Immunoglobulin Variable Region
- Mice
- Mice, Inbred Strains
- Neoplasm Transplantation
- Phenotype
- RNA, Neoplasm
- Receptors, Antigen, T-Cell
- T-Lymphocytes