Article
Molecular and cellular analysis of human T lymphocytes expressing gamma delta T-cell receptor.
Immunological reviews - 1 Apr 1991
Moretta L, Ciccone E, Ferrini S, Pelicci P G, Mingari M C, Zeromski J, Bottino C, Grossi C, Moretta A
Abstract excerpt
A minor subset of T lymphocytes expresses a CD3-associated TCR composed of gamma and delta chains. The majority of TCR gamma/delta+ cells lack surface CD4 and CD8 antigen and do not react with WT31 mAb. These negative criteria were utilized in early studies to identify TCR gamma/delta+ cells. More recently, mAb to TCR gamma/delta, selected in different laboratories, have permitted the direct identification of TCR...
Topics
- Antibodies, Monoclonal
- Antigens, Differentiation, T-Lymphocyte
- CD3 Complex
- Cytotoxicity, Immunologic
- Gene Rearrangement, T-Lymphocyte
- Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor
- Genes
- Humans
- Lymphocyte Activation
- Organ Specificity