Article
A dominant Jurkat T cell mutation that inhibits LFA-1-mediated cell adhesion is associated with increased cell growth.
Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 2001
Cherry L K, Weber K S, Klickstein L B
Abstract excerpt
LFA-1 exists in a low avidity state on resting leukocytes and is believed to adopt a high avidity state when the cells are exposed to a stimulus. Current evidence supports both aggregation of LFA-1 on the cell surface and conformational changes in the reversible acquisition of a high avidity state. We studied this regulation by selecting a Jurkat T cell clone, J-lo1.3, that expresses LFA-1 yet fails to bind to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.