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Article

A molecular basis for the association of the <i>HLA-DRB1</i> locus, citrullination, and rheumatoid arthritis

4 Nov 2013

Abstract excerpt

Rheumatoid arthritis (RA) is strongly associated with the human leukocyte antigen (HLA)-DRB1 locus that possesses the shared susceptibility epitope (SE) and the citrullination of self-antigens. We show how citrullinated aggrecan and vimentin epitopes bind to HLA-DRB1*04:01/04. Citrulline was accommodated within the electropositive P4 pocket of HLA-DRB1*04:01/04, whereas the electronegative P4 pocket of the...

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Identifiers

PMID: 24190431
DOI: 10.1084/jem.20131241

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