Article
Citrullination only infrequently impacts peptide binding to HLA class II MHC.
PloS one - 1 Jan 2017
Sidney John, Becart Stephane, Zhou Mimi, Duffy Karen, Lindvall Mikaela, Moore Erin C, Moore Eugene L, Rao Tadimeti, Rao Navin, Nielsen Morten, Peters Bjoern, Sette Alessandro
Abstract excerpt
It has been hypothesized that HLA class II alleles associated with rheumatoid arthritis (RA) preferentially present self-antigens altered by post-translational modification, such as citrullination. To understand the role of citrullination we tested four RA-associated citrullinated epitopes and their corresponding wild-type version for binding to 28 common HLA class II. Binding patterns were variable, and no...
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