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The molecular basis underlying T cell specificity towards citrullinated epitopes presented by HLA-DR4

23 Jul 2024

Abstract excerpt

Abstract CD4+ T cells recognising citrullinated self-epitopes presented by HLA-DRB1 bearing the shared susceptibility epitope (SE) are implicated in rheumatoid arthritis (RA). However, the underlying T cell receptor (TCR) determinants of epitope specificity towards distinct citrullinated peptide antigens, including vimentin-64cit59-71 and α-enolase-15cit10-22 remain unclear. Using HLA-DR4-tetramers, we examine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39043656
DOI: 10.1038/s41467-024-50511-w

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