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Article

Arthritogenic peptide binding to DRB1*01 alleles correlates with susceptibility to rheumatoid arthritis.

Journal of autoimmunity - 1 Aug 2016

Roark Christina L, Anderson Kirsten M, Aubrey Michael T, Rosloniec Edward F, Freed Brian M

Abstract excerpt

Genetic susceptibility to rheumatoid arthritis (RA) is often defined by the presence of a shared epitope (QKRAA, QRRAA, or RRRAA) at positions 70-74 in HLA-DRβ1. However, DRβ1*01:01 and 01:02 contain the same QRRAA epitope, but differ considerably in their susceptibility to RA. The purpose of this study was to determine if this difference could be explained by their ability to bind three arthritogenic peptides...

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Share to Arthritis, Rheumatoid
Share to Collagen Type II

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to HLA-DRB1 Chains

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Share to Phosphopyruvate Hydratase

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Source

Identifiers

PMID: 27143337
DOI: 10.1016/j.jaut.2016.04.006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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