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Article

CENP-R acts bilaterally as a tumor suppressor and as an oncogene in the two-stage skin carcinogenesis model.

Cancer science - 1 Nov 2017

Okumura Kazuhiro, Kagawa Naoko, Saito Megumi, Yoshizawa Yasuhiro, Munakata Haruka, Isogai Eriko, Fukagawa Tatsuo, Wakabayashi Yuichi

Abstract excerpt

CENP-R is a component of the CENP-O complex, including CENP-O, CENP-P, CENP-Q, CENP-R, and CENP-U and is constitutively localized to kinetochores throughout the cell cycle in vertebrates. CENP-R-deficient chicken DT40 cells are viable and show a very minor effect on mitosis. To investigate the functional roles of CENP-R in vivo, we generated CENP-R-deficient mice (Cenp-r-/- ). Mice heterozygous or homozygous for...

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Identifiers

PMID: 28795467
DOI: 10.1111/cas.13348
PMCID: PMC5665765

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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