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Article

Mouse skin chemical carcinogenesis is inhibited by antizyme in promotion-sensitive and promotion-resistant genetic backgrounds.

Molecular carcinogenesis - 1 Jun 2007

Feith David J, Shantz Lisa M, Shoop Paula L, Keefer Kerry A, Prakashagowda Chethana, Pegg Anthony E

Abstract excerpt

Elevated polyamine content and increased ornithine decarboxylase (ODC) activity have been associated with neoplastic growth in numerous animal models and human tissues. Antizyme (AZ) is a negative regulator of polyamine metabolism that inhibits ODC activity, stimulates ODC degradation, and suppresses polyamine uptake. Preliminary evidence, obtained from transgenic mice with tissue specific overexpression of AZ...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17219416
DOI: 10.1002/mc.20294

Genes

PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Mouse skin chemical carcinogenesis is inhibited by antizyme in promotion-sensitive and promotion-resistant genetic backgrounds.PMID 17219416Read ↗

Overexpression of a dominant-negative ornithine decarboxylase in mouse skin: effect on enzyme activity and papilloma formation.Semantic proximity Read ↗

Tumor suppressor activity of ODC antizyme in MEK-driven skin tumorigenesis.Semantic proximity Read ↗

Polyamines modulate carcinogen-induced mutagenesis in vivo.Semantic proximity Read ↗

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Conversion of C57Bl/6 mice from a tumor promotion-resistant to a -sensitive phenotype by enhanced ornithine decarboxylase expression.Semantic proximity Read ↗

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Haploinsufficiency for odc modifies mouse skin tumor susceptibility.Semantic proximity Read ↗

Regulation of ornithine decarboxylase.Semantic proximity Read ↗

Targeted expression of spermidine/spermine N1-acetyltransferase increases susceptibility to chemically induced skin carcinogenesis.Semantic proximity Read ↗

Enhanced induction of epidermal ornithine decarboxylase activity in C57BL/6 compared to DBA/2 mice by protein kinase C-activating skin tumor promoters: relevance to genetically mediated differences in promotion susceptibility.Semantic proximity Read ↗

Analysis of ras gene mutational spectra in epidermal papillomas from K6/ODC transgenic mice.Semantic proximity Read ↗

Induction of epithelial differentiation and DNA demethylation in hamster malignant oral keratinocyte by ornithine decarboxylase antizyme.Semantic proximity Read ↗

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