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Article

ras activity and cyclin D1 expression: An essential mechanism of mouse skin tumor development

1 Jan 1999

Abstract excerpt

ras is a family of small GTP-binding proteins that transduce signals from tyrosine-kinase receptors to the nucleus and thus play a role in the regulation of cell proliferation and differentiation. Several lines of evidence have shown that the cell-cycle machinery, specifically the circuit cyclin D1/cyclin-dependent kinase (cdk) 4 and 6-p16-pRb, lies downstream of ras. Point mutations that activate the ras protein...

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PMID: 10029404
DOI: 10.1002/(sici)1098-2744(199901)24:1<1::aid-mc1>3.0.co;2-e

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