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Article

Tumor suppressor activity of ODC antizyme in MEK-driven skin tumorigenesis.

Carcinogenesis - 1 May 2006

Feith David J, Origanti Sofia, Shoop Paula L, Sass-Kuhn Suzanne, Shantz Lisa M

Abstract excerpt

To test the hypothesis that suppression of ornithine decarboxylase (ODC) activity blocks the promotion of target cells in the outer root sheath of the hair follicle initiated by Raf/MEK/ERK activation, we crossed mice overexpressing an activated MEK mutant in the skin (K14-MEK mice) with two transgenic lines overexpressing antizyme (AZ), which binds to ODC and targets it for degradation. K14-MEK mice develop...

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Identifiers

PMID: 16400186
DOI: 10.1093/carcin/bgi343

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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