Article
The genetic control of chemically and radiation-induced skin tumorigenesis: a study with carcinogenesis-susceptible and carcinogenesis-resistant mice.
Radiation research - 1 Jul 2002
Pazzaglia Simonetta, Mancuso Mariateresa, Rebessi Simonetta, Di Majo Vincenzo, Tanori Mirella, Biozzi Guido, Covelli Vincenzo, Saran Anna
Abstract excerpt
Outbred carcinogenesis-resistant (Car-R) and carcinogenesis-susceptible (Car-S) mouse lines were generated by phenotypic selection for resistance or susceptibility to two-stage skin carcinogenesis. These two Car mouse lines differ by >100-fold in susceptibility. In the present study, we tested the hypothesis that a subset of genetic loci responsible for susceptibility or resistance to chemical skin tumorigenesis...
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