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Article

Increased Systemic Exposure and Stronger Cardiovascular and Metabolic Adverse Reactions to Fenoterol in Individuals with Heritable OCT1 Deficiency.

Clinical pharmacology and therapeutics - 1 May 2018

Tzvetkov Mladen V, Matthaei Johannes, Pojar Sherin, Faltraco Frank, Vogler Sabrina, Prukop Thomas, Seitz Tina, Brockmöller Jürgen

Abstract excerpt

Fenoterol is a widely used anti-asthmatic and tocolytic agent, but high plasma concentrations of fenoterol may lead to severe and even fatal adverse reactions. We studied whether heritable deficiency of the liver organic cation transporter 1 (OCT1), a trait observed in 3% of Europeans and white Americans, affects fenoterol plasma concentrations and toxicity. OCT1 transported fenoterol with high affinity, and OCT1...

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Identifiers

PMID: 28791698
DOI: 10.1002/cpt.812

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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