Article

CAVIN1-Mediated Endocytosis: A Novel Mechanism Underlying The Interindividual Variability In Drug-Induced Long QT

2023-02-23

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Drug-induced QT prolongation (diLQT) is a feared side-effect as exposing susceptible individuals to fatal arrhythmias. The occurrence of diLQT is primarily attributed to unintended drug interactions with cardiac ion channels, notably the hERG channels that generate the repolarizing current (IKr) and thereby regulate the late repolarization phase. There is an important inter-in...

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Literature Corpus work: 49923191-8f24-5eb9-bd24-92d584b9fc66
DOI: 10.1101/2023.02.21.23286271

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