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Article

Genetic variants in multidrug and toxic compound extrusion-1, hMATE1, alter transport function.

The pharmacogenomics journal - 1 Apr 2009

Chen Ying, Teranishi Kristen, Li Shuanglian, Yee Sook Wah, Hesselson Stephanie, Stryke Doug, Johns Susan J, Ferrin Thomas E, Kwok Pui, Giacomini Kathleen M

Abstract excerpt

hMATE1 (human multidrug and toxin compound extrusion-1; encoded by SLC47A1) is thought to have an important function in the renal and hepatic elimination of drugs, endogenous compounds and environmental toxins. The goals of this study were to identify genetic variants of hMATE1 and to determine their effects on hMATE1 transport function. We identified four synonymous and six nonsynonymous, coding region variants...

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Identifiers

PMID: 19172157
DOI: 10.1038/tpj.2008.19
PMCID: PMC2949062

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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