Article
Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1.
Proceedings of the National Academy of Sciences of the United States of America - 13 May 2003
Shu Yan, Leabman Maya K, Feng Bo, Mangravite Lara M, Huang Conrad C, Stryke Doug, Kawamoto Michiko, Johns Susan J, DeYoung Joseph, Carlson Elaine, Ferrin Thomas E, Herskowitz Ira, Giacomini Kathleen M
Abstract excerpt
The organic cation transporter, OCT1, is a major hepatic transporter that mediates the uptake of many organic cations from the blood into the liver where the compounds may be metabolized or secreted into the bile. Because OCT1 interacts with a variety of structurally diverse organic cations, including clinically used drugs as well as toxic substances (e.g., N-methylpyridinium, MPP(+)), it is an important...
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