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Hepatic solute carrier transporters and drug therapy: Regulation of expression and impact of genetic variation.

Pharmacology & therapeutics - 1 Oct 2022

Nies Anne T, Schaeffeler Elke, Schwab Matthias

Abstract excerpt

Organic cation transporters (OCT), organic anion transporting polypeptides (OATP) and organic anion transporters (OAT) from the solute carrier (SLC) family play an essential role in the uptake of endogenous compounds and drugs into the hepatocytes and other cell types. The well-documented interindividual variability of expression and activity of these transporters translates into interindividual variability in...

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Drug Transport and Resistance Mechanisms
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Organic Anion Transporters

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PMID: 35995278
DOI: 10.1016/j.pharmthera.2022.108268

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