Article
Inborn errors in RNA polymerase III underlie severe varicella zoster virus infections.
The Journal of clinical investigation - 1 Sept 2017
Ogunjimi Benson, Zhang Shen-Ying, Sørensen Katrine B, Skipper Kristian A, Carter-Timofte Madalina, Kerner Gaspard, Luecke Stefanie, Prabakaran Thaneas, Cai Yujia, Meester Josephina, Bartholomeus Esther, Bolar Nikhita Ajit, Vandeweyer Geert, Claes Charlotte, Sillis Yasmine, Lorenzo Lazaro, Fiorenza Raffaele A, Boucherit Soraya, Dielman Charlotte, Heynderickx Steven, Elias George, Kurotova Andrea, Auwera Ann Vander, Verstraete Lieve, Lagae Lieven, Verhelst Helene, Jansen Anna, Ramet Jose, Suls Arvid, Smits Evelien, Ceulemans Berten, Van Laer Lut, Plat Wilson Genevieve, Kreth Jonas, Picard Capucine, Von Bernuth Horst, Fluss Joël, Chabrier Stephane, Abel Laurent, Mortier Geert, Fribourg Sebastien, Mikkelsen Jacob Giehm, Casanova Jean-Laurent, Paludan Søren R, Mogensen Trine H
Abstract excerpt
Varicella zoster virus (VZV) typically causes chickenpox upon primary infection. In rare cases, VZV can give rise to life-threatening disease in otherwise healthy people, but the immunological basis for this remains unexplained. We report 4 cases of acute severe VZV infection affecting the central nervous system or the lungs in unrelated, otherwise healthy children who are heterozygous for rare missense mutations...
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