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Article

Varicella-zoster virus CNS vasculitis and RNA polymerase III gene mutation in identical twins

7 Sept 2018

Abstract excerpt

OBJECTIVE: Deficiency in the cytosolic DNA sensor RNA Polymerase III (POL III) was recently described in children with severe varicella-zoster virus (VZV) infection in the CNS or lungs. Here, we describe a pair of monozygotic female twins, who both experienced severe recurrent CNS vasculitis caused by VZV reactivation. The clinical presentation and findings included recurrent episodes of headache, dizziness, and...

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PMID: 30211253
DOI: 10.1212/nxi.0000000000000500

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