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Article

Herpes simplex virus encephalitis of childhood: inborn errors of central nervous system cell-intrinsic immunity.

Human genetics - 1 Jun 2020

Zhang Shen-Ying

Abstract excerpt

Herpes simplex virus 1 (HSV-1) encephalitis (HSE) is the most common sporadic viral encephalitis in Western countries. Over the last 15 years, human genetic and immunological studies have provided proof-of-principle that childhood HSE can result from inborn errors of central nervous system (CNS)-specific, cell-intrinsic immunity to HSV-1. HSE-causing mutations of eight genes disrupt known (TLR3-dependent IFN-α/β...

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Identifiers

PMID: 32040615
DOI: 10.1007/s00439-020-02127-5
PMCID: PMC7739442

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