Article
Mutations in RNA Polymerase III genes and defective DNA sensing in adults with varicella-zoster virus CNS infection.
Genes and immunity - 1 Mar 2019
Carter-Timofte Madalina E, Hansen Anders F, Christiansen Mette, Paludan Søren R, Mogensen Trine H
Abstract excerpt
Recently, deficiency in the cytosolic DNA sensor RNA Polymerase III was described in children with severe primary varicella-zoster virus (VZV) infection in the CNS and lungs. In the present study we examined adult patients with VZV CNS infection caused by viral reactivation. By whole exome sequencing we identified mutations in POL III genes in two of eight patients. These mutations were located in the coding...
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