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Article

RNA Polymerase III as a Gatekeeper to Prevent Severe VZV Infections.

Trends in molecular medicine - 1 Oct 2018

Carter-Timofte Madalina E, Paludan Søren R, Mogensen Trine H

Abstract excerpt

In most individuals, varicella zoster virus (VZV) causes varicella upon primary infection and zoster during reactivation. However, in a subset of individuals, VZV may cause severe disease, including encephalitis. Host genetics is believed to be the main determinant of exacerbated disease manifestations. Recent studies have demonstrated that defects in the DNA sensor RNA polymerase III (POL III) confer selective...

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PMID: 30115567
DOI: 10.1016/j.molmed.2018.07.009

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