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RNA Polymerase III Subunit Mutations in Genetic Diseases

30 Jul 2021

Abstract excerpt

RNA polymerase (Pol) III transcribes small untranslated RNAs such as 5S ribosomal RNA, transfer RNAs, and U6 small nuclear RNA. Because of the functions of these RNAs, Pol III transcription is best known for its essential contribution to RNA maturation and translation. Surprisingly, it was discovered in the last decade that various inherited mutations in genes encoding nine distinct subunits of Pol III cause...

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PMID: 34395528
DOI: 10.3389/fmolb.2021.696438

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