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Article

Inborn errors of human transcription factors governing IFN-γ antimycobacterial immunity.

Current opinion in immunology - 1 Apr 2023

Ogishi Masato, Yang Rui, Rosain Jérémie, Bustamante Jacinta, Casanova Jean-Laurent, Boisson-Dupuis Stéphanie

Abstract excerpt

Inborn errors of immunity (IEI) delineate redundant and essential defense mechanisms in humans. We review 15 autosomal-dominant (AD) or -recessive (AR) IEI involving 11 transcription factors (TFs) and impairing interferon-gamma (IFN-γ) immunity, conferring a predisposition to mycobacterial diseases. We consider three mechanism-based categories: 1) IEI mainly affecting myeloid compartment development (AD GATA2 and...

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Identifiers

PMID: 36867972
DOI: 10.1016/j.coi.2023.102296
PMCID: PMC10023504

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