Article
Diverse mutational pathways converge on saturable chloroquine transport via the malaria parasite's chloroquine resistance transporter.
Proceedings of the National Academy of Sciences of the United States of America - 29 Apr 2014
Summers Robert L, Dave Anurag, Dolstra Tegan J, Bellanca Sebastiano, Marchetti Rosa V, Nash Megan N, Richards Sashika N, Goh Valerie, Schenk Robyn L, Stein Wilfred D, Kirk Kiaran, Sanchez Cecilia P, Lanzer Michael, Martin Rowena E
Abstract excerpt
Mutations in the chloroquine resistance transporter (PfCRT) are the primary determinant of chloroquine (CQ) resistance in the malaria parasite Plasmodium falciparum. A number of distinct PfCRT haplotypes, containing between 4 and 10 mutations, have given rise to CQ resistance in different parts of the world. Here we present a detailed molecular analysis of the number of mutations (and the order of addition)...
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